Invincibility in "The Binding of Isaac Rebirth"

i wanted to ask you guys, if there is a way to be invincible in "The Binding Of Isaac Rebirth" (with an item combo). I once heared about something with the cursed scull.

asked Oct 28, 2015 at 13:56 460 5 5 silver badges 14 14 bronze badges

2 Answers 2

1. Version:

So basically you can't die. Lets say Yum Heart is empty and you have 1 1/2 hearts left:

Of course, you have to be quick with the Yum Heart, but this is pretty much the best invincibility combo in the game.

2. Version (even better)

With this powerful Setup, you have unlimited hearts and you can clear rooms quickly. This works forever if you don' drop below 2.5 hearts since you can just activate the blank card at 2.5 hearts and will be fully restored thanks to the sun. You can also spam spacebar in order to activate multiple sun cards in a row, which can clear rooms quite quickly.

Other Options, even though not that strong:

Can't think of anything which made me really invincible . maybe I'll edit this post if I remember something else.